Short-term amlodipine induced liver injury : an extremely rare acute complication

Toxic liver injury comprises an insidious and potentially devastating complication of pharmaceutical preparations. Drug-induced hepatotoxicity may virtually mimic any form of chronic or acute liver disease (1). Amlodipine is a long-acting dihydropyridine calcium antagonist used as an anti-hypertensive agent (2). Treatment with amlodipine is usually well-tolerated and overwhelming majority of adverse reactions reported during amlodipine treatment are of mild or moderate severity (3). Herein, we report of an unusual and extremely rare case with short- term amlodipine induced hepatotoxicity (liver injury). A 46 year-old man was admitted to the cardiology clinic for refractory hypertension.